2(2)-1基本信息 |
姓名: |
Frederick William Orr? |
性别: |
男? |
出生年月: |
1942年11月? |
最终学历: |
M.D.? |
职称: |
? |
电话: |
(204)789-3338;0754-8900429? |
学位: |
M.D.? |
职务: |
Chairman? |
传真: |
0754-8900429? |
所在院系: |
Department of Pathology,University of Manitoba? |
E-Mail: |
fworr2004@yahoo.ca? |
通信地址(邮编): |
Department of Patholog University of Manitoba D212 – 770 Bannatyne Avenue Winnipeg, Manitoba R3E 0W3, CANADA? |
研究方向: |
Cancer Metastasis? | |
2(2)-2教学情况 |
近五年来讲授的主要课程:
课? 程 名? 称 |
类 别 |
周学时 |
届 数 |
学生总人数 |
《疾病与临床CPC讨论课》 |
专业基础课 |
2 |
2 |
300
(汕大医学院) |
General pathology & CPC |
专业基础课 |
2 |
3 |
University of Manitoba |
Anatomical Pathology |
专业基础课 |
2 |
3 |
University of Manitoba |
Cancer Metastasis
? |
专业基础课 |
2 |
3 |
University of Manitoba |
Biology of Neoplasia. |
专业基础课 |
2 |
3 |
University of Manitoba |
?
?
承担的实践性教学:
2000-2005年期间:
1.2003年起 汕头大学医学院病理学教研室客座教授,合编 active problem-based? format《General Graphic Pathology》全英教改教材(伴标准英语讲解),提供CPC素材与典型图片2000例。
2. 2004年参加汕头大学医学院整合式教改的主干模块课程之一 —?— 疾病与临床CPC讨论课02级本科生“修复”章节的主讲教授与全程实验课教学。
3.2005年与苏敏教授合编 active problem-based? format《General Graphic Pathology》全英教改教材,完成全程标准英语讲解授课的录像录音,开设全英病理网络课程。
?
主持的教学研究课题
1.2004年广东省精品课程汕头大学医学院病理学课程15万元(其中学院配套经费5万元) 担任病理学全英教学主讲教授。
2.全国高等教育科学“十五”规划重点课题 “面向21世纪以问题为中心的和谐式开放式CPC病理教学法系列配套教材” 2002-2005 图、文、音、影立体、动态全英病理学教材《Graphic general pathology》主要编写作者之一
3.广东省高校现代教育技术“151工程”第三批立项项目 基于网络资源利用以问题为中心的CPC病理学教学法研究? 2004担任病理学全英教学主讲教授(网络教学)
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发表的教学研究论文及主编参编著作
1.Weber, M.H. and Orr, F.W.? Pathological Principles of Bone Metastasis.? In, Diel, I.J. (Ed)? Bisphosphonates in Oncology.? Springer, Heidelberg (In Press).
2.Orr, F.W. and Wang, H.H.? Tumor Cell Interactions with the Microvasculature:? A Rate-Limiting Step in Metastasis.? In Brodt, P. (Ed)? Metastasis:? Biological and Clinical Aspects.? Surgical Clinics of North America.? 10: 357-382, 2001.
3.Wang,H.H., Scherbarth, S.S., Mcintosh, A., Hasinoff, B., Rector, E., Ahmed, N., Nance, D., and Orr, W.? Regulation of Cancer Metastasis to the Liver by the Hepatic Microvasculature.? In Wisse, E. (Ed).? Cells of the Hepatic Sinusoid? Vol 8.? Kupffer Cell Foundation, Leyden? 8: 161-165, 2001. ? |
2(2)-3学术研究 |
?Research Grants
1.Cancer cell/endothelial cell interactions in hepatic metastasis.1997-2000 Medical Research Council of Canada.??? With Dwight Nance.Operating grant - $81,263/year?
2.Regulation of cancer metastasis by the hepatic microvasculature. Canadian Instutues for Health Research.? With Dwight Nance April 2001 to March? 2004 (Operating Grant - $$87,582/year).
3.Detection and quantitative evaluation of bone metastases by magnetic resonance imaging.National Science and Engineering Research Council.? With Jonathan Sharp (National Research Council for Biodiagnostic Imaging), Dean Kreillaars, and Peter Watson. (Operating grant - $21,000/year from 1999 to 2003).
Main publication list
1.Weber,M., Lee,J, and? Orr, FW.? The effect of Neovastat (AE-941) on and experimental metastatic bone tumor model.? Int. J. Oncology 2002; 20: 299-303.
2.Wang,H.H., McIntosh, A.R., Hasinoff, B.B., MacNeil, B., Nance, D.M. and Orr, F.W. ?Modulation of the fate of melanoma cells in the liver by manipulating hepatic microvascular functions using bacterial lipopolysaccharide. European Journal of Cancer 2002; 9: 1261-1270
3.Weber,M.H., Sharp,J.C., Hassard,T.H., and Orr, F.W.? Normal murine bone morphometry:? A comparison of magnetic resonance microscopy to micro x-ray and histology.? Skeletal Radiology 2002; 31: 282-291.
4.Vukmirovic-Popovic, S., Colterjohn,N., Lhotak,S., Duivenvoorden,W.C.M., Orr,F.W. and Singh, G.? Morphological, Histomorphometric, and Microstructural Alterations in Human Bone Metastasis from Breast Carcinoma.? Bone 2002; 31, 529-535.
5.Qiu, H., Orr, FW., Jensen, D., Wang, H.H., McIntosh, A.A., Hasinoff, B., Nance, D.W., Pylypas, S., Song, C., Muschel, R., Al-Mehdi, A.B.,? Arrest of? B16 melanoma cells ????in the ?? mouse pulmonary microcirculation induces eNOS-dependent nitric oxide release that is ? cytotoxic to the tumor cells.? American Journal of Pathology? 2003; 162 ? | |